Landmark trial
Preservation of Memory With Conformal Avoidance of the Hippocampal Neural Stem-Cell Compartment During Whole-Brain Radiotherapy for Brain Metastases (RTOG 0933): A Phase II Multi-Institutional Trial
Gondi V, Pugh SL, Tome WA, et al. · RTOG
DoseLab summary
Single-arm phase 2 trial of hippocampal-avoidance whole-brain radiotherapy, 30 Gy in 10 fractions, compared with a historical control; it showed less memory decline at 4 months. Its protocol defined the hippocampal contouring and dose limits later used in NRG CC001. Citation checked against Crossref.
Why this is useful
The phase 2 trial that established hippocampal avoidance and its contouring and planning credentialing.
Reference details
- Title
- Preservation of Memory With Conformal Avoidance of the Hippocampal Neural Stem-Cell Compartment During Whole-Brain Radiotherapy for Brain Metastases (RTOG 0933): A Phase II Multi-Institutional Trial
- Authors / organization
- Gondi V, Pugh SL, Tome WA, et al. · RTOG
- Publication / protocol
- J Clin Oncol. 2014;32(34):3810–3816
- Version
- Pending verification
- Year
- 2014
- DOI
- 10.1200/JCO.2014.57.2909
- Disease sites
- CNS / Brain
- Topics
- Whole brain, Hippocampal avoidance, Brain metastases, Landmark trial
- Fractionation context
- 30 Gy / 10 fx
- Last reviewed by DoseLab
- Pending verification