Landmark trial
Long-term results of hypofractionated radiation therapy for breast cancer
Whelan TJ, Pignol JP, Levine MN, et al.
DoseLab summary
Ten-year results of the Ontario Clinical Oncology Group randomized trial comparing 42.5 Gy in 16 fractions with 50 Gy in 25 fractions of whole-breast irradiation after breast-conserving surgery, without a boost. Many clinics prescribe the schedule as 42.56 Gy (2.66 Gy × 16). Citation as given in the eviQ reference list; not yet checked against the journal.
Why this is useful
Ten-year results of the Canadian trial behind 16-fraction whole-breast treatment, the basis of the 42.56 Gy / 16 fx schedule in common use.
Reference details
- Title
- Long-term results of hypofractionated radiation therapy for breast cancer
- Authors / organization
- Whelan TJ, Pignol JP, Levine MN, et al.
- Publication / protocol
- N Engl J Med. 2010;362(6):513–520
- Version
- Pending verification
- Year
- 2010
- DOI
- Pending verification
- Disease sites
- Breast
- Topics
- Breast, Whole breast, Hypofractionation, Landmark trial
- Fractionation context
- 42.5 Gy/16 fx vs 50 Gy/25 fx
- Last reviewed by DoseLab
- Pending verification