Consensus CT delineation guidelines for head and neck organs at risk from eight cooperative groups, with anatomical descriptions and example images. Citation checked against Crossref; content not yet reviewed by DoseLab.
Brachial Plexus
Dose constraints
Head & Neck Planning Essentials
| Schedule | Constraint | Source |
|---|---|---|
| Conventional fractionation 70 Gy / 35 fx definitive · 60–66 Gy / 30–33 fx post-op | Max ≤66 Gy | Timmerman 2022 |
Target coverage takes priority.
Quoted from eviQ 5049, checked 2026-09-24. Full table with references →
Anatomy
A network of nerves formed from the ventral rami of C5–T1. It passes between the anterior and middle scalene muscles, over the first rib and under the clavicle into the axilla, traveling alongside the subclavian and then axillary vessels.
Function in the body
The nerves that run from the neck into the arm. They control the muscles of the shoulder, arm and hand and carry feeling back from them.
Why it matters
Injury causes brachial plexopathy — pain, weakness or numbness in the arm — which can be permanent. In lung, it matters most for apical (superior sulcus) tumors and for supraclavicular nodal targets. In SBRT tables it is treated as a serial structure with a point-dose limit. In head and neck treatment it lies next to the lower neck nodal levels (IV and V), so it is evaluated whenever the lower neck is treated; target coverage usually takes priority.
How to contour
The plexus is hard to see on CT, so Brouwer 2015 defines it by the anatomy around it (Table 1):
- Top: the top of the C5 vertebral body.
- Bottom: the top of the T3 vertebral body.
- Front: the back edges of the anterior scalene muscle, the subclavian artery and the axillary vein.
- Back: the front edges of the middle scalene, serratus anterior and subscapularis muscles.
- Outside: the outer edges of the anterior and middle scalene muscles, the pectoralis major and the teres major.
- Inside: the intervertebral foramen (bony vertebral body) and the outer edge of the first rib.
On the lowest slices, where the plexus wraps around the vessels, the vessels are included in the contour. Brouwer's supplement gives a step-by-step technique based on the Hall 2008 method. Sources commonly define the plexus per side.
Describes and validates a standardized CT-based method for delineating the brachial plexus, developed in patients treated with IMRT for head and neck cancer.
Further reading
- RTOG 0813 protocol — RTOG 0813 protocol — SBRT for centrally located NSCLC Source
- RTOG 0915 protocol — RTOG 0915 protocol — SBRT for peripheral stage I NSCLC Source
- Timmerman 2022 — A Story of Hypofractionation and the Table on the Wall Source